(Not from me) Decode 23andme for MTHFR genes
Decode 23andme for MTHFR genes
2 min read
To find out what MTHFR mutation you might have using your 23andme data, you will need to dig down into the raw data. MTHFR is involved in folate metabolism.
Note that for 23andme, MTHFR mutations are shown on the positive strand (+).
Log in to your 23andme account in order to access the links below.
MTHFR A1298C: rs1801131
https://www.23andme.com/you/explorer/snp/?snp_name=rs1801131
MTHFR A1298C: rs1801131
https://www.23andme.com/you/explorer/snp/?snp_name=rs1801131
The risk allele is G*.
- GG = homozygous for MTHFR A1298C (+/+)
- GT = heterozygous for MTHFR A1298C (+/-)
- TT = no SNP of MTHFR A1298C (-/-)
The risk allele is A.
- AA = homozygous for MTHFR C677T (+/+)
- AG = heterozygous for MTHFR C677T (+/-)
- GG = no SNP of MTHFR C677T (-/-)
Compound Heterozygous
A1298C=GT + C677T=AG is referred to as “Compound Heterozygous” meaning one has a single copy of each mutation.
A1298C=GT + C677T=AG is referred to as “Compound Heterozygous” meaning one has a single copy of each mutation.
The compound heterozygous MTHFR mutation occurs in 20% of the general population.
Promethease
There is freeware available to parse through the 23andme RawData: Promethease.
- Download your raw data here: https://www.23andme.com/you/download/
- Get Promethease here: http://www.snpedia.com/index.php/Promethease
- Run Promethease and load the 23andme zip file
It has to chunk through 17,000 genotypes so it might take several hours. Mine took EIGHT HOURS.
There is also an online paid version for $5 which takes 20 minutes.
Genetics Genie
This is a cool free service (buy hey they take donations) which connects directly with 23andMe which will do an analysis of the various SNPs that are relevant in methylation.
It’s a nifty little service that takes a few seconds and will give you a quick and dirty interpretation of your results. (Note: the prescriptions and interpretations of the results offered below the table are open to debate.
References:
http://blog.stickyrice.net/archives/2013/decode-23andme-for-mthfr-genes/
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